Endocrine Abstracts

Introduction: The importance of the liver-X receptors (LXRs) in the maintenance of cholesterol homeostasis within the testis has yet to be fully characterised. By 7 months of age, Lxrα/β double knockout male mouse (Lxrα/β DKO) develops sterility with aberrations in testosterone production and lipid homeostasis. However, the underlying testicular LXR-regulated pathways are not well understood.Aim: The aim of this study was to further u...

Introduction: LXRs are transcription factors that regulate cholesterol homeostasis and likely modulate other aspects of lipid metabolism. In the testis, tightly regulated lipid metabolism is crucial to maintain fertility. Testicular LXRs are highly expressed but their role in regulating lipid homeostasis is not fully understood. Lxrα/β double knockout male mice (Lxrα/β DKO) are sterile by 7 months of age, with aberrations in lipid...

Liver X receptors (LXRs) are are ligand-dependent transcription factors, members of the nuclear receptor superfamily of transcription factors. In humans two LXR isoforms exist, LXRα (NR1H3) and LXRβ (NR1H2). LXRα is expressed predominantly in metabolically active tissues, while LXRβ is expressed in the majority of tissues. They have long been known to have critical roles in regulation of lipid metabolism, particu...

Journal of Endocrinology, 2019, 245(1): 39–51 (DOI: https://doi.org/10.1530/JOE-19-0413)...